Keith Henderson was raised in Aberdeenshire and London. He studied at the Slade School of Art and then at the Academie de la Grande Chaumiere in Paris. While in Paris, he shared a studio with Maxwell Armfield. He served in both World Wars as a war artist. Between the two wars, he travelled extensivelly in Africa and South America where he produced many images of the flora and fauna that he saw on these trips and would later include in his book illustrations. He illustrated many books and designed posters for London Transport and the Empire Marketing Board.